Pilot and Feasibility Program


  • Pilot and Feasibility Program Overview
    • Pilot and Feasibility Investigators

    Boston Nutrition Obesity Research Center

    Pilot and Feasibility Investigators


    Investigator Project Dates Pilot and Feasibility Project Title
    Stuart Chipkin 1992-1993 Obesity and insulin resistance in adipose
    Nawfal Istfan 1992-1993 Nutrient partitioning and insulin resistance in obesity
    Kathleen Kelly 1992-1994 Signal transduction in adipocytes
    Donald Miller 1992-1994 Long term health impact of body weight change
    Aviva Must, PhD 1992-1993 Jump start: a program to prevent obesity in low income children and families
    Susan Roberts, PhD 1992-1994 Dietary fat-genotype interactions in energy balance
    Van Cherington 1993-1995 Non-receptor tyrosine kinase activity during adipose differentiation
    Bradford Lowell 1993-1995 Targeted disruption of the Beta3-andrenergic receptor gene
    Avron Spiro III 1993-1995 Health effects of weight changes in adult males
    Karen Strehlow 1993-1994 Sympathetic function in obesity
    Vildan Civelek 1994-1996 Mechanism of intracellular pH change as indicator of early postreceptor insulin signaling
    Kathleen Cook 1994-1996 Developmental and physiological mechanisms for regulation of mRNA stability in adipocytes
    Robert Frederich 1994-1996 Initial characterization, physiology and pathology of the ob/ob gene product
    Andrew Greenberg, MD 1994-1996 Molecular and nutritional regulation of the perilipins
    Eleftheria Maratos-Flier 1994-1996 Identification of novel hypothalamic genes that are differentially regulated in rodent obesity
    Jacqueline Stephens 1994-1995 The identification of cytosolic kinases involved in the signal transduction of TNF-induced insulin resistance in murine adipocytes
    Steven Grinspoon 1995-1997 Physiologic effects of IGF-1 in anorexia nervosa
    James Hamilton, PhD 1995-1997 Fatty acid incorporation into adipocytes: nuclear magnetic resonance studies
    Konstantin Kandror, PhD 1995-1997 GLUT4-containing vesicles: new proteins-new functions?
    James Kirkland, MD, PhD 1995-1997 Effects of aging on rat preadipocyte function
    Vedrana Susulic 1995-1996 Identification of nutritionally responsive cis-regulatory elements within the obese gene
    Jesse C. Chow, PhD 1996-1997 Leptin receptor signaling in normal rats in vivo
    Mary-Elizabeth Patti, MD 1996-1997 Role of amino acids in the induction of cellular insulin resistance
    Evan Dale Abel, MD, PhD 1996-1998 Analysis of the impact of adipose tissue glucose transport on body weight, nutrient partitioning and glucose tolerance
    Anthony Hollenberg, MD 1996-1998 Functional antagonism between C/EBP and PPAR on the leptin promoter
    Wen Guo, PhD 1997-1999 Effects of Exogenous Lipids on Fat Cell Metabolism
    Jim Xiao, PhD 1997-1999 Role of cyclin-dependent kinase inhibitors in differentiation of preadipocytes with aging
    Rupert Yip, PhD 1997-1999 The role of glucose-dependent insulinotropic polypeptide in fat metabolism
    Zhijun Luo, PhD 1998-2000 Role of MAPK family downstream of TNFa-receptor in insulin resistance
    Christos Mantzoros, MD 1998-2000 Role of leptin in the neuroendocrine response to fasting
    Megan McCrory, PhD 1998-2000 Evaluation of the BOD POD air displacement plethysmograph for measuring body composition of obese and elderly subjects
    Ron Morrison, PhD 1998-2000 Molecular mechanisms contributing to the balance of adipocyte growth and differentiation
    Edward Saltzman, MD 1998-2002 Feasibility of low and moderate intensity interventions to prevent weight gain in adults
    Antonio Vidal-Puig 1998-2000 Functional characterization of uncoupling proteins (UCPs) using adenoviral mediated gene transfer
    S. Bryn Austin 1999-2002 Assessment of environmental influences on diet, dieting, and physical activity in middle schools: A pilot instrument development project
    Young-Bum Kim, PhD 1999-2001 Signaling pathways mediating the effects of leptin on fat metabolism in muscle and adipose tissue
    Tatyana Kupriyanova, PhD 1999-2001 Isolation and identification of novel proteins in Glut4-vesicles
    David Ludwig, MD 1999-2001 Dietary glycemic index and diabetes
    Karen Miller 1999-2001 Effects of dietary fat on leptin and menstrual function
    Eric Rimm 1999-2002 Effects of dietary and lifestyle characteristics on soluble tumor necrosis factor-receptors (sTNF-R) and IL-6 concentrations
    Nicholas Tritos 1999-2001 Characterization of the role of melanin concentrating hormone in glucose homeostasis employing a knockout and a transgenic model
    Jude Deeney, PhD 2001-2003 Lipid distribution in clonal pancreatic beta-cells studied with fluorescent fatty acids
    Deborah Good, PhD 2001-2003 Gene regulatory events mediating adult body weight control
    Jianrong Han 2002-2004 A new mechanism for adipocyte hyperplasia: fatty acids stimulates preadipocyte proliferation
    Lora Heisler, PhD 2001-2003 Central melanocortin and serotonergic systems: potential target pathways for obesity
    Frank Hu 2001-2003 Longitudinal analysis of dietary factors and childhood obesity in China
    Jeffrey Lemmer 2001-2002 Effect of sarcopenia on body composition and energy expenditure response to progressive resistance training
    Christina Wee 2001-2003 Quantifying how much patients value weight loss
    Janice Zabolotny, PhD 2001-2003 Role of protein tyrosine phosphatase 1B in leptin and insulin action in hypothalamus
    Hui Hong Zhang, PhD 2003-2005 The domains and mechanisms by which perilipin A modulate lipase actions on lipolysis
    Nina Balthasar 2003-2005 Assessing the physiological function of melanocortin-4-receptors (MC4R) in specific brain areas using a re-activatable MC4R null allele
    Simin Liu 2003-2005 Glycemic load, insulin sensitivity and plasma inflammatory markers in Type 2 diabetic patients: a randomized, controlled, crossover trial
    Carine Lenders 2003-2005 A multicenter randomized, placebo controlled, double blind trial of metformin in obese adolescents: characterization of amino acids
    Iphigenia Tzameli 2003-2005 Identification of endogenous PPARg ligands during an early phase of adipocyte differentiation
    Kendra Bence, PhD 2003-2005 Role of tyrosine phosphates in CNS control of energy balance
    Harveen Dhillon, PhD 2004-2006 VMH: A critical site in BW regulation of leptin
    Adam Kennedy, PhD 2004-2006 The molecular mechanism of ketogenic diet in the treatment of obesity
    Lori Pbert 2004-2006 Feasibility and structure of a systems-based intervention to prevent and treat obesity
    Pavlos Pissios, PhD 2004-2006 Generation of conditionally immortalized cell lines expressing melanin-concentrating hormone (MCH)
    Diane Song, PhD 2004-2006 Characterization of GIP signaling in adipocytes
    Gordon Yaney, PhD 2004-2005 Beta-cell hypersecretion seen in obesity: Alteration of the fatty acid incretin effect?
    Jeffrey Zigman, MD, PhD 2004-2006 Selective expression of the ghrelin receptor (GHSR) within the arcuate nucleus
    R. Wesley Farris II, MD 2005-2007 The Role of Insulin-Degrading Enzyme in Obesity and Metabolism
    Erin Kershaw, MD 2005-2007 Regulation of Adipose Triglyceride Lipase (ATGL) by Insulin, TNF alpha, and PPAR gamma
    Keith Tornheim, PhD 2005-2007 Phosphofructokinase-M and adipose mass
    Yu-Hua Tseng, PhD 2005-2007 Role of BMPs on determination of brown vs. white adipocyte differentiation
    Ouliana Ziouzenkova, PhD 2005-2007 Studies on Retinaldehyde Functions in Adipogenesis
    Caroline M. Apovian, MD 2006-2008 Use of MCT Oil for Enhancement of Weight Loss and Glycemic Control in Obese Diabetic Patients
    Michael Badman, MD, PhD 2006-2009 Determination of the physiological role and Metabolic Effects of Fibroblast Growth Factor 21
    Katherine Strissel, PhD 2006-2008 Do infiltrating macrophages have a role in adipose tissue remodeling in obesity?
    Rob M. van Dam, PhD 2006-2009 Effects of caffeinated and decaffeinated coffee on body weight and glucose tolerance     
    Alvaro Pascual-Leone, MD, PhD 2007-2009 Modulation of the dorsolateral prefontal cortex with repetitive transcranial magnetic stimulation in obesity
    Bruce Bailey, PhD 2007-2009 The influence of active gaming on energy expenditure and time spent in moderate to vigorous activity in overweight adolescents
    Jamie Bodenlos, PhD 2007-2008 Effect of acute VNS on consumption and preferences for sweets in depressed adults
    Jody Dushay, MD 2007-2009 Potential regulation of FGF-21 by fasting and diet-induced ketosis in healthy adults
    Efi Kokkotou, MD, PhD, DSC 2007-2009 Mechanisms of substance P effects on metabolism
    Madhusmita Misra, MD, MPH 2007-2010 Neuroendocrine modulation of metabolic effects in overweight adolescent girls
    Sherry Pagoto, PhD 2007-2009 The role of stress in insulin resistance following bariatric surgery
    Libin Liu, PhD 2007-2009 The Role of Cavin/PTRF in Caveolae
    Lu Qi, MD, PhD 2007-2009 Genome-Wide Association Based Scan for Abdominal Obesity Genes in Humans
    Nicholas Stylopoulos, MD 2008-2009 Effects of Roux-En-Y Gastric Bypass on Diet Induced Thermogenesis in Mice
    Qingchun Tong, PhD 2007-2009 To Determine the Function of GABA Release from Agrp Neurons
    Aaron Cypess, MD, PhD 2008-2009 Characterizing murine and human brown adipose tissue via PET/CT
    Giulio Romeo, MD 2008-2009 Effects of profilin-1 in diet-induced obesity and adipose inflammation correlation with vascular outcomes
    Jess Haines, PhD, MHSc, RD 2008-2009 Maternal influences on adolescent weight and weight-related behaviors
    Mark Herman, MD 2008-2009 The role of adipose tissue carbohydrate response element binding protein (ChREBP) in adipose tissue glucose metabolism and glucose homeostasis
    Jongsoon Lee, PhD 2008-2009 The role of circulating monocytes in the development of obesity-induced inflammation and insulin resistance
    Yiqing Song, MD, ScD 2008-2009 Interrelationship of circulating levels of vitamin D, adiposity, and risk of developing type 2 diabetes in postmenopausal women
    Qi Sun, MD, ScD 2008-2009 Obesity, physical activity, and successful aging
    Thien Tran, PhD 2008-2009 Identification of novel secretory proteins from subcutaneous fat that improve metabolism
    Raphael Zoeller, PhD 2008-2009 Use of a lipogenic mutant to investigate a novel link between carbohydrate and lipid metabolism
    Hideo Makimura, MD, PhD 03/01/10-02/28/12 The Effects of a Novel GH Releasing Factor on Mitochondrial Function
    Vishwajeet Puri, PhD 03/01/10-02/28/12 Role of FSP27 in fat metabolism and insulin sensitivity
    Lisa Quintiliani, PhD, RD 03/01/10-02/28/12 A computer-based cue system for motivational interviewing counseling
    Vetrivelan Ramalingam, PhD 03/01/10-02/28/12 Sleep loss and circadian dysregulation - important risk factors for obesity and diabetes mellitus
    Zhao Xu, PhD 03/01/10-02/28/12 The role of promyelocytic leukemia zinc finger (PLZF) in adipogenesis
    Sudha Biddinger, MD, PhD 04/01/11-03/31/12 Novel mechanisms by which insulin regulates the LDL receptor
    Nicolas M. Oreskovic, MD, MPH 04/01/11-03/31/13 Use of GPS to Map Racial Variations in Adolescent Use of Space for Physical Activity
    Linh Vong, PhD 04/01/11-03/31/12 Leptin Action on GABAergic Neurons
    Heather J. Baer, ScD 04/01/11-03/31/13 Development of Tools within Electronic Health Records to Address Overweight and Obesity
    Barbara Nikolajczyk, Ph.D. 04/01/11-03/31/13 The Role of T cells in the Transition to Type 2 Diabetes
    Elaine W. Yu, MD 04/01/11-03/31/13 Effects of Bariatric Surgery on Bone Health
    Katya Ravid, DSc, PhD 04/01/11-03/31/13 The A2b adenosine receptor as regulator of type II diabetes
    Fang Fang Zhang, MD, PhD 04/01/11-03/31/13 Obesity Among ALL Survivors: Preliminary Investigation of Diet and Energy Balance
    Qin Yang, MD, PhD 04/01/11-03/31/13 Nicotinamide N-methyltransferase (NNMT) in obesity and insulin resistance
    Dong Kong, PhD 04/01/12-03/31/14 Ghrelin, Dendritic Spines, and Synaptic Regulation of AgRP Neurons
    Matthew Layne, PhD 04/01/12-03/31/14 Role of ACLP in adipocyte determination and fibrosis
    Tamar Rose Aprahamian, PhD 04/01/12-03/31/14 Angiogenic potential and thermogenic response of brown adipose tissue
    Miguel Alonso-Alonso, MD, MPhil 04/01/12-03/31/15 Neuroband: The effect of perioperative enhancement of the brain circuit of inhibitory control in obese patients undergoing laparoscopic adjustable gastric banding
    Valentina Perissi, PhD 04/01/12-03/31/14 Ubiquitin regulation of PPARgamma-mediated transcription
    Elizabeth A. Lawson, MD 04/01/12-09/31/15 The effect of intranasal oxytocin on caloric intake in obese men
    Mark Andermann, PhD 04/01/13-03/31/15 Effects of ghrelin receptor expression in cognitive brain areas on attention to food-associated cues
    Marc Liesa-Roig, PhD 04/01/13-03/31/15 A novel antioxidant pathway in beta cell function and dysfunction
    John C. Yoon, MD PhD 04/01/13-03/31/15 Effects of inhibiting the Wnt signaling pathway on diet-induced myosteatosis
    Sara Folta, PhD 12/01/13-11/30/15 Preliminary Investigation of Civic Engagement as a Novel Approach to Behavior Change and Body Weight Improvement in African American Females
    Kristy Townsend, Ph.D. 12/01/13-11/30/15 Novel Role for Hemojuvelin in Brown Adipocyte Energy Expenditure
    Peter J Turnbaugh, PhD 12/01/13-08/31/14 Gut microbial promotion of energy gain from processed diets
    Xaralabos Varelas, PhD 12/01/13-11/30/15 Roles of the Hippo pathway effectors Taz/Yap in mesenchymal stem cell fate specification
    Gulcin Pekkurnaz, Ph.D. 12/1/14-08/31/16 O-GlcNAcylation: A Glucose Sensing Pathway for Mitochondria and Energy Homeostasis
    Ying Bao, MD, ScD 12/1/14-11/30/16 Nut consumption, adiposity signals, and cardiometabolic risk
    Xinghui Sun, Ph.D. 12/1/14-7/31/16 MicroRNA-181b, insulin resistance, and vascular injury
    Maria Dafne Cardamone, Ph.D. 08/01/15-07/31/17 Role of NEURL4 in the regulation of Mitochondrial Function
    Peter James, MHS, Sc.D. 08/01/15-07/31/16 Integrating mHealth Approaches to Assess Contextual Exposures, Physical Activity, Sleep, and Obesity in a Prospective Cohort Study
    Elvira Isganaitis, MD, MPH 08/01/15-07/31/17 Mesenchymal stem cell fate and adipocyte function in mother-to-child transmission of obesity risk
    John N. Campbell, PhD 01/01/17-12/31/17 Novel arcuate neuron types that relay leptin signaling to the melanocortin satiety circuit
    Sylvia Ley, PhD, RD 01/01/17-12/31/17 Anti-inflammatory diet and gene expression on type 2 diabetes progression in overweight/obese adult
    Xuehong Zhang, MD, ScD 01/01/17-12/31/17 Characterizing the Role of Obesity in Bladder Cancer Progression in Two Large Prospective Cohorts